Cholibrium Review: Can a Mushroom Blend Lower Cholesterol?
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Cholibrium is a two-capsule daily supplement from Simple Promise that combines ten mushrooms, including reishi, lion’s mane, cordyceps, shiitake and maitake, and is sold for cholesterol, triglycerides and blood pressure. This review checks its label, the study behind its “80 points” claim, what mushroom trials in people actually found, and the prices and 365-day refund.
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Cholibrium at a Glance
Cholibrium is a Simple Promise capsule with ten mushrooms, sold for cholesterol, triglycerides and blood pressure. Two capsules give 1,330 mg of mushroom powders and extracts, with amounts for four of them. Its “80 points” claim comes from a rat study, and in human trials reishi, its best-studied mushroom, did not lower cholesterol. It is not a substitute for a statin.
- Price: $39 to $59 per bottle, depending on the package
- Refund window: 365-day money-back guarantee
- Our score: 2.9/5 (Below average) · how we scored it
What Cholibrium is
Cholibrium is a capsule supplement from Simple Promise, a supplement brand whose sales pages give an address in Camas, Washington. It is sold on a ClickBank sales page at cb.cholibrium.com and in the brand’s own online store. The sales page calls it an “Okinawan mushroom” formula whose fiber makes your body pass cholesterol out in the stool. You take two capsules a day, 20–30 minutes before a meal, and a bottle lasts 30 days. Simple Promise also sells VenoPlus 8, which we review separately.
What is in it
The ClickBank sales page shows no label, but the Supplement Facts label on the brand’s store lists, per two capsules:
- Cordyceps (Cordyceps sinensis) mycelium powder: 266 mg
- Reishi (Ganoderma lucidum) fruiting body extract: 266 mg
- Shiitake (Lentinus edodes) fruiting body extract: 266 mg
- Lion’s mane (Hericium erinaceus) fruiting body: 266 mg
- Proprietary blend, 266 mg in total: maitake, turkey tail, chaga, royal sun agaricus, white button and wood ear mushroom extracts
That is 1,330 mg of mushroom material a day. The label gives no extract ratios and no beta-glucan content, the fiber the sales page credits for the effect, and the six mushrooms in the blend share 266 mg, about 44 mg each on average. The other ingredients are the vegetable capsule, microcrystalline cellulose and magnesium stearate.
Where the “80 points” claim comes from
The sales page headline promises to lower cholesterol “by 80 points”, and the page credits a study in the journal Bioscience, Biotechnology, and Biochemistry on yamabushitake, the Japanese name for lion’s mane. That 2003 study was in rats fed a high-fat diet. They were given a substance that lion’s mane releases when it is grown in liquid culture, not the mushroom powder in the capsule, and their total cholesterol fell by about a third compared with untreated rats. No people took part.
The page’s other headline figures follow the same pattern:
- Maitake: the study the page cites for maitake fiber making you excrete more cholesterol was a four-week study in rats whose diet was 5% mushroom fiber.
- Reishi and blood pressure: the claim that reishi cut blood pressure by up to 19.5% in four hours was measured in a strain of hypertensive rats, using a specially digested reishi extract.
- Cordyceps and chaga: the cholesterol studies the brand cites used hamsters, rats and diabetic mice, and the cordyceps study used cordycepin from a different species, Cordyceps militaris.
- Shiitake: the store’s reference for shiitake lowering cholesterol is an analysis of vitamin D and sterol levels in mushrooms bought in US stores, which did not test cholesterol in anyone.
What happened when people took reishi
Reishi is the best-studied mushroom in the formula, and the results in people are disappointing:
- In the trial the sales page cites, 26 people with borderline raised blood pressure or cholesterol took 1.44 g of reishi a day and a placebo, for 12 weeks each. HDL rose and triglycerides fell during the first period only, carry-over effects prevented a full analysis, and blood pressure did not change.
- In a larger trial, 84 people with type 2 diabetes and metabolic syndrome took 3 g of reishi a day, with or without cordyceps, or a placebo for 16 weeks. The mushrooms had no effect on blood sugar or on any other measure the trial tested.
- A Cochrane review of five trials with 398 people found that reishi did not significantly lower total or LDL cholesterol in the trials that could be combined.
Mushroom fiber is real, and soluble fibers do lower LDL cholesterol: in a meta-analysis of 58 trials, about 3.5 g of oat beta-glucan a day lowered LDL by about 7 mg/dL. But Cholibrium’s whole daily dose is 1.33 g of mushroom material, and the label does not say how much of it is beta-glucan.
What the marketing says about statins
The sales page is written as the story of “Robert Johnson”, a retiree who has a heart attack, argues with his doctor to stay off statins and lowers his cholesterol with mushrooms instead; a footnote says the names have been changed. It calls statins “liver-pounding drugs”, and a customer quote describes how they “threw out the statins”. The page also repeats a limited-stock warning throughout and claims 31,169 success stories.
This is the part of the page we would most warn readers about. After a heart attack, cholesterol-lowering medicine is standard care because it works: in an analysis of 26 large trials with about 170,000 people, every 39 mg/dL drop in LDL cholesterol cut major heart attacks, strokes and artery procedures by about a fifth. No mushroom supplement has been shown to prevent a heart attack. Never stop a statin without talking to your doctor.
Side effects and who should check first
- Medicines: the mushrooms were well tolerated in trials, but several are studied for effects on blood sugar and the immune system. Ask a pharmacist first if you take medicine for diabetes or blood pressure, blood thinners or drugs that suppress the immune system.
- Allergies: avoid it if you are allergic to mushrooms or molds.
- Get your numbers checked: high cholesterol causes no symptoms. Ask your doctor for a cholesterol test and an estimate of your 10-year risk of heart attack and stroke, which decides whether you need medicine.
- Chest pain is an emergency: call emergency services for chest pain or pressure, shortness of breath, or pain spreading to the arm, jaw or back.
Price and which package makes sense
One bottle costs $59, three cost $147 ($49 each) and six cost $234 ($39 each), all with free shipping. The three- and six-bottle packages add three e-books on desserts, smoothies and food labels. It is a one-time payment, not a subscription, and the brand’s own store lists the same prices. The only reliable way to judge it is a repeat cholesterol test after two to three months, and the year-long refund leaves time for that. Our Cholibrium buying guide has the details.
The guarantee and the fine print
The written refund policy is simpler than the sales page suggests. The page describes the guarantee as a “3-step promise”, including that your cholesterol must return to the healthy range, but the policy says that if you are not happy, you can return the bottles within a year, even empty, for 100% of the purchase price. You post them to the Simple Promise Returns Centre in Federalsburg, Maryland, with your name and order number, and then contact support with a photo of the postage receipt. The policy does not mention a prepaid label, so expect to pay the postage.
Realistic expectations
Expect little or no change in your cholesterol from Cholibrium. If your LDL is high, plant sterols (1.5–2.4 g a day) lower it by about 7–10%, psyllium by about 13 mg/dL, and statins by far more. Our guide to cholesterol supplements compares the options.
🧪 Key Ingredients
What is in the formula, with a short note on each ingredient:
🌿 Reishi Extract (266 mg)
The best-studied mushroom here. A Cochrane review found no significant effect on total or LDL cholesterol, and a 16-week trial of 3 g a day found no benefit.
🌿 Lion’s Mane (266 mg)
The “80 points” claim comes from a rat study of a substance lion’s mane makes when grown in liquid culture, not the mushroom powder.
🌿 Cordyceps Mycelium (266 mg)
The cholesterol study the brand cites used cordycepin from a different species, in hamsters and rats.
🌿 Shiitake Extract (266 mg)
Contains beta-glucan fiber, but the label gives no amount, and the store’s reference is a vitamin D analysis, not a cholesterol trial.
🌿 Mushroom Blend (266 mg)
Maitake, turkey tail, chaga, royal sun agaricus, white button and wood ear share 266 mg; the cholesterol studies cited for them are mostly in animals.
*Always consult with your physician before starting any new supplement.
✅ Pros
- Amounts on the label for four of its ten mushrooms (266 mg each).
- A 365-day refund that accepts empty bottles.
- $59 a bottle with free shipping and a one-time payment.
❌ Cons
- The “80 points” headline comes from a rat study, not people.
- In human trials, reishi did not lower total or LDL cholesterol.
- Six mushrooms share a 266 mg blend, with no extract ratios or beta-glucan content.
- The sales page presents refusing statins after a heart attack as a success story.
- The label is on the brand’s store, not the ClickBank sales page.
What Specific Issues Can Cholibrium Help With?
Based on the formula and our research, this product is frequently considered for the following health concerns:
Choose Your Package
365-Day Money-Back Guarantee
Simple Promise’s refund policy for ClickBank orders is one of the most generous we have seen. You have a year from purchase to ask for 100% of the purchase price back, even if the bottles are empty. Post the bottles, used, unused or empty, to the Simple Promise Returns Centre in Federalsburg, Maryland, with your name and order number on a sheet of paper, then contact support and send a photo of the postage receipt or the tracking number. The policy does not mention a prepaid return label, so expect to pay the postage. Refunds are processed up to two weeks after the return arrives, plus 10–14 business days for your bank.
Frequently Asked Questions
Cholibrium is a capsule supplement from Simple Promise, sold through ClickBank and the brand’s own store for cholesterol, triglycerides and blood pressure. Two capsules a day provide 1,330 mg of ten mushrooms, including reishi, lion’s mane, cordyceps, shiitake and maitake.
Per two capsules: cordyceps mycelium powder 266 mg, reishi extract 266 mg, shiitake extract 266 mg, lion’s mane 266 mg, and a 266 mg blend of maitake, turkey tail, chaga, royal sun agaricus, white button and wood ear mushroom extracts.
There is no good evidence that it does. It has not been tested itself, its headline claim comes from a rat study, and in human trials reishi, its best-studied mushroom, did not lower total or LDL cholesterol. Only a repeat blood test would show whether it does anything for you.
No. Statins lowered heart attacks and strokes in trials involving about 170,000 people; no mushroom supplement has been shown to. The sales page encourages distrust of statins, but you should never stop one without talking to your doctor.
It is a real product sold through ClickBank by Simple Promise, with a label on the brand’s store and a year-long refund that accepts empty bottles. But its cholesterol claims rest on animal studies, and its sales page uses a story of refusing statins after a heart attack to sell it.
Both come from Simple Promise. We rate VenoPlus 8 slightly higher (3.2 out of 5 against 2.9) because it lists every amount and some of its ingredients have human evidence, though mostly at lower doses than the trials. Neither has been shown to lower cholesterol, and VenoPlus 8 is aimed more at blood pressure and circulation.
One bottle costs $59, three cost $147 ($49 each) and six cost $234 ($39 each), all with free shipping. The three- and six-bottle packages add three e-books. It is a one-time payment.
Within a year of purchase, post the bottles, even empty ones, to the Simple Promise Returns Centre in Federalsburg, Maryland, with your name and order number, then contact support with a photo of the postage receipt. You get 100% of the purchase price back, but expect to pay the return postage.
The mushrooms were generally well tolerated in trials. Avoid it if you are allergic to mushrooms or molds, and ask a pharmacist first if you take medicine for diabetes or blood pressure, blood thinners or drugs that suppress the immune system.
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For a limited time, get the 6 Bottles for just $234 ($39/bottle).
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See Why Everyone's Choosing This →How we scored Cholibrium
Five weighted criteria — see our full methodology.
Whether the label discloses how much of each ingredient it contains, rather than hiding amounts inside a proprietary blend.
Whether the finished product has been tested in a published trial, or the claims rest on research into individual ingredients.
Monthly cost on the three-month package, the shortest course most vendors recommend (the single price for one-off digital products), compared against the rest of the category.
Length of the refund window measured against the trial period the vendor itself recommends.
How the product is sold: sales channel, checkout upsells, subscription defaults and how clearly the offer is presented.
The label, published on the brand’s own store rather than the sales page, gives amounts for four of the ten mushrooms (266 mg each of cordyceps mycelium, reishi extract, shiitake extract and lion’s mane) and puts the other six in a 266 mg blend, with no extract ratios or beta-glucan content. Evidence scores low: the sales page’s headline promise to lower cholesterol “by 80 points” comes from a rat study, and in people, reishi did not lower total or LDL cholesterol in a Cochrane review or in a 16-week trial of 3 g a day. Buying practices score lowest: the page tells the story of a heart attack survivor who argued his way off statins, quotes a customer who “threw out the statins”, and repeats a limited-stock warning. Value, free shipping and the 365-day refund, which accepts empty bottles, are its strong points.
Final Verdict
Cholibrium is a mushroom blend with a partly open label: 266 mg each of cordyceps, reishi, shiitake and lion’s mane, plus six more mushrooms sharing a 266 mg blend. The evidence behind its cholesterol claims comes almost entirely from rats and mice. In people, reishi did not lower total or LDL cholesterol in a Cochrane review of five trials, or in a 16-week trial of 3 g a day.
The 365-day refund, which accepts empty bottles, limits the money you could lose. The bigger risk is the sales page, which presents refusing statins after a heart attack as a success story. Statins lower the risk of heart attacks and strokes in large trials; no mushroom supplement has been shown to. If your cholesterol is high, plant sterols, psyllium and oats have far better evidence, and our cholesterol guide compares them. Never stop a prescribed statin without talking to your doctor.
Why Trust This Review?
We check claims against published research and score every product with the same published rubric. We earn a commission if you buy through our links (disclosure); it never changes a score.
- ✓ Scored with our published rubric
- ✓ Claims checked against published research
- ✓ Refund terms checked
- ✓ Affiliate commissions disclosed
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