VenoPlus 8 Review: What Is in It, and Can It Clear Your Arteries?

What VenoPlus 8 is

VenoPlus 8 is a powdered drink supplement from Simple Promise, the brand behind Cholibrium. It is sold on a ClickBank sales page at cb.venoplus8.com and in the brand’s own online store. You mix one 5.4 g scoop into about 10 fl oz of water once a day; a jar holds 30 servings and is green apple flavored. The sales page presents it as a formula built around a Japanese “supernutrient” that fights “plaque protein”, raises nitric oxide and balances blood pressure and cholesterol.

What is in it

The ClickBank sales page shows no label, but the Supplement Facts label on the brand’s store lists, per scoop:

• Vitamin K2 (as menaquinone-7, MenaQ7): 80 mcg
• Beetroot extract (RedNite, standardized to 1.5% nitrates): 800 mg, which supplies about 12 mg of nitrate
• Pomegranate whole fruit extract (standardized to 30% punicalagins): 150 mg
• Hesperidin (from oranges): 100 mg
• Grape seed extract (standardized to 95% polyphenols): 75 mg
• Vitamin C (as magnesium ascorbate): 90 mg, 100% of the Daily Value
• Magnesium (as magnesium ascorbate): 7 mg, 2% of the Daily Value
• Inulin (chicory root fiber): 2,700 mg

The other ingredients are natural flavors, malic and citric acid, silica, the sweetener sucralose and salt; a scoop has 10 calories and 2 g of fiber. Inulin is by far the largest ingredient, although the sales page never mentions it. The seller’s affiliate page lists L-arginine, L-citrulline and taurine among ten ingredients, but none of the three is on the label.

Vitamin K2 and the “plaque protein”

The sales page builds its case on MenaQ7, a branded form of vitamin K2 like the one found in natto, a Japanese fermented soybean dish. Vitamin K2 activates matrix Gla protein (MGP), which helps stop calcium building up in artery walls; the page calls the inactive form of MGP “plaque protein”. The evidence for vitamin K2 is real but modest:

• In a three-year trial in 244 healthy postmenopausal women, 180 mcg of MenaQ7 a day improved measures of arterial stiffness and lowered inactive MGP by 50% compared with a placebo.
• In a 12-week trial in 60 adults, 180 and 360 mcg a day lowered inactive MGP by 31% and 46%, with no change in other heart risk factors.
• In a 2026 trial in 180 people with coronary artery disease, 360 mcg a day for two years slightly slowed the build-up of calcium in the heart arteries; calcium scores still rose in both groups.

VenoPlus 8 contains 80 mcg, less than half the lowest of those doses. We could not match the page’s figures of a 93% drop in “plaque protein” in six weeks or a 1,215% rise in artery flexibility to a placebo-controlled trial, and inactive MGP is a marker of vitamin K status, not plaque itself. The page also says vitamin K2 cuts heart attack risk by half. The best-known study linking vitamin K2 to half the risk of dying from heart disease is the Rotterdam Study, in which people who ate the most vitamin K2 in food had fewer heart deaths. That is an observational link from diet, not a trial of a supplement.

The other ingredients

• Beetroot extract: nitrate from beetroot lowers blood pressure. In a trial in 68 people with high blood pressure, a daily 250 mL glass of beetroot juice with about 6.4 mmol (roughly 400 mg) of nitrate lowered readings by about 8 mmHg systolic over four weeks. The 800 mg of extract in VenoPlus 8 supplies about 12 mg of nitrate, around 3% of that dose. More on beetroot.
• Pomegranate extract: the page’s claim that it cuts artery wall thickness by 30% matches a study of 10 patients who drank pomegranate juice. In a larger trial, 289 people drank a glass of pomegranate juice or a control drink daily for up to 18 months, with no overall difference in artery wall thickening.
• Hesperidin: 500 mg a day for three weeks improved artery function in a small trial of 24 people with metabolic syndrome. VenoPlus 8 has 100 mg.
• Grape seed extract: a meta-analysis of 16 small trials found it lowered blood pressure by about 6/3 mmHg, although the authors noted that results were often hard to reproduce. More on grape seed.
• Inulin: a prebiotic fiber that slightly lowered triglycerides in meta-analyses, with only low-certainty evidence for LDL cholesterol. It can cause gas and bloating at first. More on inulin.
• Vitamin C and magnesium: 90 mg of vitamin C is about what a glass of orange juice provides, and 7 mg of magnesium is too little to matter. More on magnesium.

None of these ingredients has been shown to lower LDL cholesterol by much, and no supplement has been shown to remove plaque from arteries.

What the marketing promises

The sales page says VenoPlus 8 works by “scrubbing away arterial plaque”, that within days it will balance “even the most erratic blood pressure”, and that its nutrients come in the amounts clinical research says are necessary. As shown above, most of the doses are well below those used in trials. The page is narrated by “Jonathan Parker”, described in a footnote as a Simple Promise researcher whose name has been changed, offers its discount to the first 250 people, and quotes a customer saying that all drugs are harmful. If an ad like this brought you here, keep taking any blood pressure or cholesterol medicine you have been prescribed.

Side effects and who should check first

• Warfarin and other vitamin K antagonists: avoid VenoPlus 8. In a study of volunteers taking an anticoagulant of this type, as little as 10–20 mcg of vitamin K2 a day weakened its effect to a clinically relevant degree in 40–60% of them; VenoPlus 8 has 80 mcg. The label gives only a general warning to consult a healthcare provider. Newer blood thinners such as apixaban do not work through vitamin K, but ask your pharmacist.
• Blood pressure medicines: several ingredients are meant to lower blood pressure, so check your readings if you take medicine for it.
• Digestion: the 2.7 g of inulin can cause gas, bloating or loose stools, especially at first.
• Chest pain is an emergency: call emergency services for chest pain or pressure, shortness of breath, or pain spreading to the arm, jaw or back.

Price and which package makes sense

One jar costs $59, three cost $147 ($49 each) and six cost $234 ($39 each). The seller’s shipping policy for ClickBank orders says shipping is free, and the three- and six-jar packages add two bonus guides and a breathing video. It is a one-time payment, not a subscription, and the brand’s own store lists the same prices. Our VenoPlus 8 buying guide has the details.

The guarantee and the fine print

VenoPlus 8 has the same refund policy as Cholibrium: within a year of purchase, you can return the jars, even empty, for 100% of the purchase price. You post them to the Simple Promise Returns Centre in Federalsburg, Maryland, with your name and order number, then contact support with a photo of the postage receipt. The policy does not mention a prepaid label, so expect to pay the postage.

Realistic expectations

VenoPlus 8 is unlikely to make a measurable difference to your cholesterol, and at these doses any effect on blood pressure would be small. The vitamin K2 trials that showed effects used 180–360 mcg a day, and even those effects were modest. Our guides to supplements for blood pressure and cholesterol compare the options with stronger evidence.